Investigation of antioxidant, enzyme inhibition and antiproliferative activities of blackthorn (Prunus spinosa L.) extracts

Natural products have a key role in drug discovery pharmacology and medicine. Prunus spinosa L. (blackthorn) grown Çanakkale province western Turkey, is known as medicinal plant, rich source of biologically active compounds such phenolics, flavonoids anthocyanidins. The flower fruit extracts the plant are subjects many studies, but they usually lack details its potential for bio-inhibition studies. Thus, this study aimed to investigate antioxidant, enzyme inhibition antiproliferative activity studies methanol, ethyl acetate, dichloromethane, n-hexane plant. acetate methanol demonstrated more better antioxidant with DPPH, FRAP, CUPRAC, TEAC assays. Enzyme were performed using β-lactamase various proteases. (FL) (FL L) at concentration 10 mg/mL, showed good against α-chymotrypsin, trypsin, papain values 22.6%, 34.7% 92.1%, respectively. Furthermore, displayed higher cytotoxic effect cancer cells Hep3B HT29 when compared healthy (HUVEC) MTT assay. findings suggest that P. their components may be further investigations novel candidates.